2016-2017 Catalog

Pharmacology, Physiology and Therapeutics

The Pharmacology, Physiology & Therapeutics program is no longer accepting applications.

Please go to the Biomedical Sciences page at: 

 http://und-public.courseleaf.com/graduateacademicinformation/departmentalcoursesprograms/biomedicalsciences/

The four graduate programs (Anatomy & Cell Biology, Biochemistry & Molecular Biology, Microbiology & Immunology, and Pharmacology, Physiology & Therapeutics) at the University of North Dakota School of Medicine and Health Sciences are now combined into an integrated, multi-disciplinary program in Biomedical Sciences. Students that entered the programs in fall 2014 will follow the newly developed curriculum and will become a part of the Biomedical Sciences graduate program. Students who enrolled in the four programs previous to fall 2014 will have the option of either completing degree requirements for the program in which they enrolled (found in previous UND Academic Catalogs) or transferring to and completing degree requirements for the Biomedical Sciences graduate program.

 

Master of Science (M.S.)

Admission Requirements

  1. A four-year bachelor’s degree from a recognized college or university.
  2. Successful completion of two semesters or equivalent course in general chemistry, and courses in general biology, general physics, and organic chemistry.
  3. Undergraduate courses in analytical chemistry, calculus, genetics, physiology, biochemistry and statistics are desirable.
  4. Overall undergraduate GPA of at least 3.0.
  5. GRE scores on the General Test are required.
  6. Graduate Students may be admitted to either the M.S. program or directly to the Ph.D. program
  7. Students who elect to begin the M.S. program and later decide to pursue the Ph.D. before finishing the M.S. may do so by petitioning the Departmental Faculty. This action requires a GPA in accordance with the current academic catalog.
  8. Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.
  9. Students who have received a bachelor’s degree or higher from the United States or English-speaking Canada are not required to submit the TOEFL.

Degree Requirements

Students seeking the Master of Science degree at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Physiology, Pharmacology, and Therapeutics Department.

Students are advised to consult the current approved guidelines for additional requirements or changes.

The graduate requirements for a Master of Science in Pharmacology, Physiology and Therapeutics consist of required coursework and research leading to the preparation of a thesis. In addition to the general requirements listed in the Academic Catalog, the following must be completed by all candidates for the M.S. in Pharmacology, Physiology and Therapeutics.

  1. A minimum of 30 semester credits in a major field, including the credits granted for the thesis and the research leading to the thesis.
  2. At least one-half of the credits must be at or above the 500-level
  3. A maximum of one-fourth (usually 8-9 semester credits) of the credit hours required for the degree may be transferred from another institution.

I. Coursework:

BIMD 500Cellular and Molecular Foundations of Biomedical Science6
BIMD 510Basic Biomedical Statistics2
BIMD 513Seminars in Biomedical Science1
BIMD 516Responsible Conduct of Research1
PPT 500Principles of Physiology and Pharmacology *6
PPT 521Seminar in Pharmacology, Physiology and Therapeutics1
Electives (See Elective course offerings. Three credits must be from PPT electives)6
PPT 591
PPT 998
Research in PPT
and Thesis
6
Total Credits29

 ELECTIVES

PPT 503Advanced Pharmacology or Physiology3
PPT 525Advanced Renal Physiology3
PPT 526Advanced Respiratory Physiology3
PPT 527Advanced Neurophysiology3
PPT 528Advanced Endocrinology3
PPT 529Adv Cardiovascular Physiology3
PPT 511Biochemical and Molecular Mechanisms of Pharmacology3
PPT 505Research Techniques (Note: NOT an elective for Ph.D. students)1-3
PPT 530Advanced Neurochemistry3
PPT 535Mechanisms of Neurodegenerative Disorders3
PPT 540Molecular Neuropharmacology3

 

*

A student must obtain at least a “B” in PPT 500 Principles of Physiology and Pharmacology the first time they take the course in order to remain in good standing in the PPT graduate program. If less than a “B” is received, the student may petition  the  PPT  Graduate  Faculty  in  order  to  take  the  course  a second time.

II. Teaching:

The teaching requirement will be defined by the student’s Faculty Advisory Committee and will include one semester of laboratory teaching, e.g., , or the development, presentation, and assessment of lectures related to one educational unit as defined by the instructor of record in a Pharmacology, Physiology and Therapeutics undergraduate course.

III. Research and Thesis:

The M.S. in Pharmacology, Physiology and Therapeutics requires completion of a thesis based on the results of a research project completed by the graduate student under the guidance of a faculty advisor. The project must represent an original and independent investigation by the student. It is expected that the results of the research will be published in a refereed scientific journal. The thesis prepared by the candidate must be presented and defended before the Faculty Advisory Committee and the Departmental Faculty.

 

Doctor of Philosophy (Ph.D.)

Admission Requirements

  1. A four-year bachelor’s degree from a recognized college or university.
  2. Successful completion of two semesters or equivalent course in general chemistry, and or courses in general biology, general physics, and organic chemistry.
  3. Undergraduate courses in analytical chemistry, calculus, genetics, physiology, biochemistry and statistics are desirable.
  4. Overall undergraduate GPA of at least 3.00.
  5. GRE score on the General Test are required.
  6. Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.
  7. Students who have received a bachelor’s degree or higher from the United States or English-speaking Canada are not required to submit the TOEFL.
  8. Graduate students may be admitted to either the M.S. program or directly to the Ph.D. program.
  9. Students who elect to begin the M.S. program and later decide to pursue the Ph.D. before finishing the M.S. may do so by petitioning the Department Faculty. This action requires a GPA in accordance with the current academic catalog.

Degree Requirements

Students seeking the Doctor of Philosophy degree at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Physiology, Pharmacology, and Therapeutics Department.

The graduate requirements for a Doctor of Philosophy in Pharmacology, Physiology and Therapeutics consist of required coursework, satisfactorily passing the comprehensive exam, and research leading to the preparation of a dissertation. In addition to the general requirements listed in the Academic Catalog, the following must be completed by all candidates for the Ph.D. in Pharmacology, Physiology and Therapeutics.

  1. Completion of 90 semester credits beyond the baccalaureate degree.
  2. Maintenance of at least a 3.0 GPA for all classes completed as a graduate student.
  3. At least one-half of the work must be in the major field.
  4. Successful completion of a comprehensive examination.
  5. Successful completion of dissertation.

I. Coursework:

BIMD 500Cellular and Molecular Foundations of Biomedical Science6
BIMD 510Basic Biomedical Statistics2
BIMD 513Seminars in Biomedical Science1
BIMD 516Responsible Conduct of Research1
PPT 500Principles of Physiology and Pharmacology *6
PPT 505Research Techniques3
PPT 521Seminar in Pharmacology, Physiology and Therapeutics1
Electives (See Elective course offerings. Three credits must be from PPT electives)12
PPT 591
PPT 999
Research in PPT
and Dissertation
57
Total Credits89

 ELECTIVES

PPT 503Advanced Pharmacology or Physiology3
PPT 525Advanced Renal Physiology3
PPT 526Advanced Respiratory Physiology3
PPT 527Advanced Neurophysiology3
PPT 528Advanced Endocrinology3
PPT 529Adv Cardiovascular Physiology3
PPT 511Biochemical and Molecular Mechanisms of Pharmacology3
PPT 530Advanced Neurochemistry3
PPT 535Mechanisms of Neurodegenerative Disorders3
PPT 540Molecular Neuropharmacology3

 

*

A student must obtain at least a “B” in PPT 500 Principles of Physiology and Pharmacology the first time they take the course in order to remain in good standing in the PPT graduate program. If less than a “B” is received, the student may petition the PPT Graduate Faculty in order to take the course a second time.

II. Teaching:

The teaching requirement will be defined by the student’s Faculty Advisory Committee and will include one semester of laboratory teaching, e.g., PPT 301 Human Physiology, or the development, presentation, and assessment of lectures related to one educational unit as defined by the instructor of record in a Pharmacology, Physiology and Therapeutics undergraduate course.

III. Scholarly Tools

Students must complete at least one laboratory research techniques course, e.g., PPT 505 Research Techniques at the graduate level.

IV. Research and Dissertation

The Ph.D. in Pharmacology, Physiology and Therapeutics requires completion of a dissertation based on the results of a research project completed by the graduate student under the guidance of a faculty adviser. The project must represent an original and independent investigation by the student. It is expected that the results of the research will be published in a refereed scientific journal. The dissertation prepared by the candidate must be presented and defended before the Faculty Advisory Committee and the Departmental Faculty.

BIMD Courses

BIMD 501. Scientific Discovery I. 6 Credits.

A problem based course in which students will address a set of biomedical research scenarios that have been designed so that students will acquire skills in critical thinking, finding, interpreting, and analyzing scientific literature, developing hypothesis-driven questions, proposing and designing experiments, and communicating scientific outcomes orally and in written format. F.

BIMD 502. Scientific Discovery II. 6 Credits.

A problem based course in which students will address a set of biomedical research scenarios that have been designed so that students will advance their skills in critical thinking, finding, interpreting, and analyzing scientific literature, developing hypothesis-driven questions, proposing and designing experiments, and communicating scientific outcomes orally and in written format. This course is a continuation and advancement of BIMD 501. Prerequisite: BIMD 501. S.

BIMD 510. Basic Biomedical Statistics. 2 Credits.

A series of lectures, demonstrations and exercises to provide students with the basic rationales for the use of statistics in the assessment of biomedical data and a selected set of the most common and useful statistical tests. Prerequisite: BIMD 500 or permission of course director. S.

BIMD 513. Seminars in Biomedical Science. 1 Credit.

A series of presentations on original research conducted by UND faculty members as well as extramural leaders in academic and industrial research in the biomedical sciences. Students will participate through assigned reading and writing exercises related to the presentations.

BIMD 516. Responsible Conduct of Research. 2 Credits.

A series of lectures and discussion sessions covering topics related to responsible conduct in research. Students will examine a variety of issues including introduction to ethical decision making, the experience of conflict, laboratory practices, data management, reporting of research, conflict of interest, and compliance. Examples and case studies will be drawn primarily from the biomedical sciences. F.

BIMD 518. Grant Writing. 2 Credits.

This is an advanced graduate grant writing and oral presentation course. The objectives of this course are to challenge students: (1) to critically evaluate their own research in an effort to clearly define the significance and innovation of their project, (2) to begin to develop novel ideas based on their research efforts that have the potential to significantly impact their field of study, and (3) to prepare students to present these ideas orally and in writing in a manner that is both logical and convincing. Prerequisites: BIMD 501 and BIMD 502, or consent of instructor. F.

BIMD 520. Principles of Neuroanatomy. 2 Credits.

In this course students will learn the fundamental principles of neuroscience, particularly gross and cellular anatomy, development and systems physiology of the nervous system. Behavioral, cognitive and clinical manifestations of abnormal neural functions will also be addressed. Prerequisite: BIMD 502 or permission of instructor. F.

BIMD 521. Neurophysiology. 2 Credits.

This course is designed to introduce students to the electrical properties of neuronal membranes. The course is organized to first provide a brief review of the basic properties of semi-permeable membranes. The electrical and biochemistry principles that apply to neuronal membranes are discussed. Prerequisite: BIMD 502 or consent of instructor. F.

BIMD 522. Principles of Neuropharmacology. 2 Credits.

This course is designed to introduce students to the latest developments in molecular neuropharmacology. The course directive is to provide an up-to-date foundation for clinical neuroscience by emphasizing a comprehensive molecular and cellular approach to the effects of drugs on the nervous system. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 523. Neurochemical Basis of the Nervous System. 2 Credits.

This course is designed to introduce students to fundamental concepts of brain metabolism and neurochemical signaling. It emphasizes recent advances in understanding brain biochemical processes and molecular mechanisms occurring in health and disease. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 524. Neurodegenerative Diseases and Pathophysiology. 2 Credits.

This course exposes students to diverse neurodegenerative diseases and nervous system pathophysiology. The emphasis is on mechanistic understanding of the most recent advances in the field. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 525. Readings in Neuroscience. 1-4 Credits.

A supervised readings course on topics of mutual interest to the student and a faculty member. Prerequisite: BIMD 502 or consent of instructor. Repeatable to 4 credits. On demand.

BIMD 530. Components of the Immune System. 2 Credits.

Have you ever wondered why you don't get sick every time you breathe air which can carry as many as 2000 different kinds of microbes on any given day? Or what keeps your defense system from attacking your own cells but can get rid of most invaders without you even noticing? This is the amazing task of your fascinating immune system! This course will provide an overview of cellular and molecular components of mammalian immune system and their function. The students will learn how these components are derived and how they interact and communicate with each other to coordinate a response to pathological insults in order to protect the human body. Prerequisite: BIMD 502 or consent of instructor. F.

BIMD 531. Components of Microbial Pathogenesis. 2 Credits.

The objective of the course is to provide students with a background in the mechanisms of microbial pathogenesis. Students will learn basic principles of host-parasite interactions. Paradigms of host-parasite interactions will be illustrated by studying, at the molecular and cellular levels, specific infectious diseases and the agents that cause them. Prerequisite: BIMD 502 or consent of instructor. F.

BIMD 532. Microbial Gene Regulation. 1 Credit.

This course will provide an understanding of genetic regulation in bacteria. Classic pathways will be examined as paradigms of regulatory circuits. These examples will be expanded to learn how bacteria exploit host cells as well as the use of bacterial regulatory circuits in modern molecular biology. S.

BIMD 533. Microbial Membranes and Transport. 1 Credit.

This course will explore bacterial membranes with particular emphasis on generation of energy and transport of molecules across the membranes. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 534. Microbial Cell Structure and Function. 1 Credit.

Microbial cells have unique structures that relate their functions. Students completing this course will have an understanding of how prokaryotic and eukaryotic organisms differ and how different structures can be used to obtain similar functions. They will understand how microbial structures influence interactions between microbes and between microbes and eukaryotic organisms. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 535. Bacterial Host: Pathogen Interactions. 1 Credit.

The objective of the course is to provide students with a background in the fundamental aspects that occur at the bacterial: host interface. Students will learn the interplay between bacterial virulence factors, strategies used to evade host defenses, and host responses to infection. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 536. Molecular Biology and Pathogenesis of Viruses. 1 Credit.

This course will cover the structure, replication, and pathogenesis of human RNA and DNA viruses, the host immune response to viral infection and the strategies employed by viruses to escape immune detection and elimination. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 537. Host-Pathogen Interactions involving Eukaryotic Microbes (Parasites/Fungi). 1 Credit.

Eukaryotic microbe infections have a devastating impact on global health and economic development as they infect over one third of the world's population and cause acute and chronic pathologies. Furthermore, macroscopic parasites (helminths/ worms) are master regulators of host inflammatory response and hence reduce the immune response to coinfections and negatively affect the success of vaccination programs against many other pathogens. In contrast, it has been proposed that the rise in autoimmune diseases in the developed world could be a direct result of the successful complete elimination of parasitic helminths in these communities. Thus, the purpose of this course is to provide a basic knowledge of the clinically important eukaryotic microbe pathogens and the immune response associated with their infections. A series of lectures will cover course components; a) basic introduction to protozoa, helminth, and fungi, and b) basic knowledge of the immune response and its involvement in parasitic/ fungal infections. An effort has been made to increase clinical relevance and problem-solving skills through a team-learning exercise involving quiz and paper presentations. S.

BIMD 538. Immunological Disorders. 1 Credit.

This course will include discussion of cellular and molecular immunopathologies leading to autoimmune diseases, and primary and secondary immunodeficiencies; and the role of the immune system in tumorigeneses and transplantation, as well as various methods of modification of the immune response. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 539. Readings in Microbiology and Immunology. 1-4 Credits.

A supervised readings course on topics of mutual interest to the student and a faculty member. Prerequisite: BIMD 502 or consent of instructor. Repeatable to 4 credits. On demand.

BIMD 590. Research. 1-12 Credits.

The course allows research in pertinent problems in various aspects of biomedical sciences. Repeatable. F,S,SS.

BIMD 591. Advanced Topics in Biomedical Sciences. 1-3 Credits.

A series of lectures, discussions and/or laboratory experiences developed around a specific topic in the biomedical sciences. Repeatable as topics vary. Prerequisite: BIMD 502 or consent of instructor. Repeatable to 6 credits. On demand.

BIMD 998. Thesis. 1-6 Credits.

Completion of thesis required for M.S. Repeatable to 6 credits. F,S,SS.

BIMD 999. Dissertation. 1-12 Credits.

Completion of dissertation required for Ph.D. Repeatable to 12 credits. F,S,SS.

PPT Courses

PPT 500. Principles of Physiology and Pharmacology. 6 Credits.

Graduate level survey course covering basic principles of human physiology and pharmacology. Material covered will include the physiology (how the body works) and the pharmacology (how drugs affect physiological functions) of the major organ systems. Covered also will be basic pharmacological principles including pharmacodynamics, pharmacokinetics and therapeutics. Teaching modalities used are designed to actively engage students in critical thinking and knowledge application. Prerequisite: BIMD 500 or consent of instructor.

PPT 503. Advanced Pharmacology or Physiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 505. Research Techniques. 1-3 Credits.

Prerequisite: Consent of instructor.

PPT 511. Biochemical and Molecular Mechanisms of Pharmacology. 3 Credits.

Fundamental concepts of pharmacology with emphasis on biochemical and molecular mechanisms. Prerequisites: BIMD 500 and PPT 500, or consent of instructor.

PPT 512. Special Topics in Pharmacology, Physiology and Therapeutics. 2 Credits.

An in-depth coverage of a particular topic chosen by the instructor. Prerequisite: Consent of instructor.

PPT 521. Seminar in Pharmacology, Physiology and Therapeutics. 1 Credit.

S/U grading.

PPT 525. Advanced Renal Physiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 526. Advanced Respiratory Physiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 528. Advanced Endocrinology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 529. Adv Cardiovascular Physiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 530. Advanced Neurochemistry. 3 Credits.

This course is designed to introduce graduate students to the discipline of neurochemistry. This course builds on concepts introduced in PPT 500, with an emphasis on brain biochemical processes occurring in health and disease. Prerequisite: PPT 500 or consent of instructor.

PPT 590. Readings in PPT. 1-4 Credits.

Prerequisite: Consent of instructor. Repeatable to 8 credits.

PPT 591. Research in PPT. 1-15 Credits.

Repeatable.

PPT 996. Continuing Enrollment. 1-12 Credits.

Prerequisite: Consent of instructor. Repeatable. S/U grading.

PPT 998. Thesis. 1-9 Credits.

Prerequisite: Consent of instructor. Repeatable to 9 credits.

PPT 999. Dissertation. 1-12 Credits.

Prerequisite: Consent of instructor. Repeatable.

Office of the Registrar

Tel: 701.777.2711
1.800.CALL.UND
Fax: 701.777.2696

Twamley Hall Room 201
264 Centennial Drive Stop 8382
Grand Forks, ND 58202-8382