2014-2015 Catalog

Pharmacology, Physiology and Therapeutics

http://www.med.und.nodak.edu/depts/pharm/

FACULTY: Brown-Borg, Carvelli, Chen, Combs, Doze, Geiger (Chair), Ghribi, Golovko, Haselton (Graduate Director), Henry, Lei, Murphy, Porter and Rosenberger

The four graduate programs at the University of North Dakota School of Medicine and Health Sciences are in the process of creating a combined, integrated, and multi-disciplinary program in Biomedical Sciences.  We anticipate that students entering the Pharmacology, Physiology and Therapeutics program in Fall 2014 will follow the newly developed curriculum and will become a part of the Biomedical Sciences Graduate Program.  Students previously enrolled in the Pharmacology, Physiology and Therapeutics program will have the option of completing their degree under existing requirements or transferring to the Biomedical Sciences Program.  Pending NDUS approval, information on the Biomedical Sciences Graduate Program and the course offerings will be available after July 1, 2014 at the following website: med.und.edu/basic-sciences/bimd

Degrees Granted: Master of Science (M.S.) and Doctor of Philosophy (Ph.D.)

The Pharmacology, Physiology and Therapeutics provides coursework and research opportunities leading to the M.S. and Ph.D. The research interests of our faculty cover a wide range of topics including aging, neurodegenerative disease, neurotoxicology, synaptic transmission, lipid metabolism, cardiovascular physiology, renal physiology and molecular pharmacology.

Active participation in Departmental activities such as journal discussion groups and seminars is an integral part of training and is expected of students.

Details pertaining to admission requirements, degree requirements and courses offered can be found in the Degree section.

Master of Science (M.S.)

Mission Statement and Program Goals

The mission of the Graduate Program of the Department of Pharmacology, Physiology, and Therapeutics is to train and educate students to become successful scientists by providing a rigorous academic foundation combined with cutting-edge biomedical research training.

Goal 1: Students will acquire discipline-based knowledge in pharmacology and physiology.

Goal 2: Students will develop mastery of critical thinking skills.

Goal 3: Students will develop the appropriate skills necessary to design experiments and interpret results.

Goal 4: Students will develop appropriate communication skills.

Doctor of Philosophy (Ph.D.)

Mission Statement and Program Goals

The mission of the Program of the Department of Pharmacology, Physiology, and Therapeutics is to train and educate students to become successful scientists by providing a rigorous academic foundation combined with cutting-edge biomedical research training.

Goal 1: Students will acquire discipline-based knowledge in pharmacology and physiology.

Goal 2: Students will develop mastery of critical thinking skills.

Goal 3: Students will develop the appropriate skills necessary to design experiments and interpret results.

Goal 4: Students will develop appropriate communication skills.

Combined M.D./Ph.D.

Through the cooperation of the School of Graduate Studies and the School of Medicine, students may concurrently pursue the Doctor of Philosophy degree in a medical science field (Anatomy and Cell Biology, Biochemistry and Molecular Biology, Microbiology and Immunology, Pharmacology, Physiology and Therapeutics) and the Doctor of Medicine degree. The minimum time required to complete the joint program is six years of full-time academic study.

Students interested in the joint M.D./Ph.D. program should first obtain admission to the School of Medicine and Health Sciences to the M.D. degree program, following the normal application process and meeting the selection criteria. A student admitted to the M.D. program may apply to School of Graduate Studies as soon as he/she has selected a graduate program, which may occur before matriculation in Medical School but not later than the end of the first year of Medical School.

Final admission requirements for the M.D./Ph.D. program include:

  1. Satisfactory performance in the first two years of the medical education curriculum with passing scores on all required assessment tools.
  2. Successful completion of the USMLE Step 1 examination.
  3. Satisfactory scores achieved on General and Subject GRE examination or MCAT scores.
  4. All other UND School of Graduate Studies admission requirements listed in the UND Academic Catalog.

If admission to a Ph.D. program is granted, the student should apply to the School of Medicine and Health Sciences Student Performance and Recognition Committee for a “modification of original program,” which will allow the student to pursue the M.D. degree and Ph.D. degree concurrently. The student also must request the Office of Student Affairs to certify to the School of Graduate Studies his/her satisfactory completion of the first two years of the M.D. program.

Students are expected to complete the following general requirements for the Ph.D. degree in a medical science field:

  1. Performance of original research of a quality suitable for publication in refereed, professional journals.
  2. Pass final examination which includes preparation and oral defense of a satisfactory dissertation.
  3. Completion of .
  4. A minimum of 90 credit hours, including research and dissertation.
  5. Successful completion of a scholarly tool (Note: May be specified by a department.)
  6. Completion of the first two years of the medical education curriculum, transferred as 44 credits toward the Ph.D.

 

Master of Science (M.S.)

Admission Requirements

  1. A four-year bachelor’s degree from a recognized college or university.
  2. Successful completion of two semesters or equivalent course in general chemistry, and courses in general biology, general physics, and organic chemistry.
  3. Undergraduate courses in analytical chemistry, calculus, genetics, physiology, biochemistry and statistics are desirable.
  4. Overall undergraduate GPA of at least 3.0.
  5. GRE scores on the General Test are required.
  6. Graduate Students may be admitted to either the M.S. program or directly to the Ph.D. program
  7. Students who elect to begin the M.S. program and later decide to pursue the Ph.D. before finishing the M.S. may do so by petitioning the Departmental Faculty. This action requires a GPA in accordance with the current academic catalog.
  8. Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.
  9. Students who have received a bachelor’s degree or higher from the United States or English-speaking Canada are not required to submit the TOEFL.

Degree Requirements

Students seeking the Master of Science degree at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Physiology, Pharmacology, and Therapeutics Department.

Students are advised to consult the current approved guidelines for additional requirements or changes.

The graduate requirements for a Master of Science in Pharmacology, Physiology and Therapeutics consist of required coursework and research leading to the preparation of a thesis. In addition to the general requirements listed in the Academic Catalog, the following must be completed by all candidates for the M.S. in Pharmacology, Physiology and Therapeutics.

  1. A minimum of 30 semester credits in a major field, including the credits granted for the thesis and the research leading to the thesis.
  2. At least one-half of the credits must be at or above the 500-level
  3. A maximum of one-fourth (usually 8-9 semester credits) of the credit hours required for the degree may be transferred from another institution.

I. Coursework:

BIMD 500Cellular and Molecular Foundations of Biomedical Science6
BIMD 510Basic Biomedical Statistics2
BIMD 513Seminars in Biomedical Science1
BIMD 516Responsible Conduct of Research1
PPT 500Principles of Physiology and Pharmacology *6
PPT 521Seminar in Pharmacology, Physiology and Therapeutics1
Electives (See Elective course offerings. Three credits must be from PPT electives)6
PPT 591
  & PPT 998
Research in PPT
   and Thesis
6
Total Credits29

 ELECTIVES

PPT 503Advanced Pharmacology or Physiology3
PPT 525Advanced Renal Physiology3
PPT 526Advanced Respiratory Physiology3
PPT 527Advanced Neurophysiology3
PPT 528Advanced Endocrinology3
PPT 529Adv Cardiovascular Physiology3
PPT 511Biochemical and Molecular Mechanisms of Pharmacology3
PPT 505Research Techniques (Note: NOT an elective for Ph.D. students)1-3
PPT 530Advanced Neurochemistry3
PPT 535Mechanisms of Neurodegenerative Disorders3
PPT 540Molecular Neuropharmacology3

 

*

A student must obtain at least a “B” in PPT 500 Principles of Physiology and Pharmacology the first time they take the course in order to remain in good standing in the PPT graduate program. If less than a “B” is received, the student may petition  the  PPT  Graduate  Faculty  in  order  to  take  the  course  a second time.

II. Teaching:

The teaching requirement will be defined by the student’s Faculty Advisory Committee and will include one semester of laboratory teaching, e.g., , or the development, presentation, and assessment of lectures related to one educational unit as defined by the instructor of record in a Pharmacology, Physiology and Therapeutics undergraduate course.

III. Research and Thesis:

The M.S. in Pharmacology, Physiology and Therapeutics requires completion of a thesis based on the results of a research project completed by the graduate student under the guidance of a faculty advisor. The project must represent an original and independent investigation by the student. It is expected that the results of the research will be published in a refereed scientific journal. The thesis prepared by the candidate must be presented and defended before the Faculty Advisory Committee and the Departmental Faculty.

 

Doctor of Philosophy (Ph.D.)

Admission Requirements

  1. A four-year bachelor’s degree from a recognized college or university.
  2. Successful completion of two semesters or equivalent course in general chemistry, and or courses in general biology, general physics, and organic chemistry.
  3. Undergraduate courses in analytical chemistry, calculus, genetics, physiology, biochemistry and statistics are desirable.
  4. Overall undergraduate GPA of at least 3.00.
  5. GRE score on the General Test are required.
  6. Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.
  7. Students who have received a bachelor’s degree or higher from the United States or English-speaking Canada are not required to submit the TOEFL.
  8. Graduate students may be admitted to either the M.S. program or directly to the Ph.D. program.
  9. Students who elect to begin the M.S. program and later decide to pursue the Ph.D. before finishing the M.S. may do so by petitioning the Department Faculty. This action requires a GPA in accordance with the current academic catalog.

Degree Requirements

Students seeking the Doctor of Philosophy degree at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Physiology, Pharmacology, and Therapeutics Department.

The graduate requirements for a Doctor of Philosophy in Pharmacology, Physiology and Therapeutics consist of required coursework, satisfactorily passing the comprehensive exam, and research leading to the preparation of a dissertation. In addition to the general requirements listed in the Academic Catalog, the following must be completed by all candidates for the Ph.D. in Pharmacology, Physiology and Therapeutics.

  1. Completion of 90 semester credits beyond the baccalaureate degree.
  2. Maintenance of at least a 3.0 GPA for all classes completed as a graduate student.
  3. At least one-half of the work must be in the major field.
  4. Successful completion of a comprehensive examination.
  5. Successful completion of dissertation.

I. Coursework:

BIMD 500Cellular and Molecular Foundations of Biomedical Science6
BIMD 510Basic Biomedical Statistics2
BIMD 513Seminars in Biomedical Science1
BIMD 516Responsible Conduct of Research1
PPT 500Principles of Physiology and Pharmacology *6
PPT 505Research Techniques3
PPT 521Seminar in Pharmacology, Physiology and Therapeutics1
Electives (See Elective course offerings. Three credits must be from PPT electives)12
PPT 591
  & PPT 999
Research in PPT
   and Dissertation
57
Total Credits89

 ELECTIVES

PPT 503Advanced Pharmacology or Physiology3
PPT 525Advanced Renal Physiology3
PPT 526Advanced Respiratory Physiology3
PPT 527Advanced Neurophysiology3
PPT 528Advanced Endocrinology3
PPT 529Adv Cardiovascular Physiology3
PPT 511Biochemical and Molecular Mechanisms of Pharmacology3
PPT 530Advanced Neurochemistry3
PPT 535Mechanisms of Neurodegenerative Disorders3
PPT 540Molecular Neuropharmacology3

 

*

A student must obtain at least a “B” in PPT 500 Principles of Physiology and Pharmacology the first time they take the course in order to remain in good standing in the PPT graduate program. If less than a “B” is received, the student may petition the PPT Graduate Faculty in order to take the course a second time.

II. Teaching:

The teaching requirement will be defined by the student’s Faculty Advisory Committee and will include one semester of laboratory teaching, e.g., PPT 301 Human Physiology, or the development, presentation, and assessment of lectures related to one educational unit as defined by the instructor of record in a Pharmacology, Physiology and Therapeutics undergraduate course.

III. Scholarly Tools

Students must complete at least one laboratory research techniques course, e.g., PPT 505 Research Techniques at the graduate level.

IV. Research and Dissertation

The Ph.D. in Pharmacology, Physiology and Therapeutics requires completion of a dissertation based on the results of a research project completed by the graduate student under the guidance of a faculty adviser. The project must represent an original and independent investigation by the student. It is expected that the results of the research will be published in a refereed scientific journal. The dissertation prepared by the candidate must be presented and defended before the Faculty Advisory Committee and the Departmental Faculty.

BIMD Courses

BIMD 500. Cellular and Molecular Foundations of Biomedical Science. 6 Credits.

A series of lectures and discussion groups with emphasis on interrelated themes in basic biochemistry, cell biology and molecular biology. Lectures will include current and emerging areas of research, while discussion will center on methods, techniques and expansion of lecture topics. Prerequisites: (a) a year of organic chemistry or (b) one semester of organic chemistry plus a course in either biochemistry or cell biology, or (c) permission of the course director. F.

BIMD 510. Basic Biomedical Statistics. 2 Credits.

A series of lectures, demonstrations and exercises to provide students with the basic rationales for the use of statistics in the assessment of biomedical data and a selected set of the most common and useful statistical tests. Prerequisite: BIMD 500 or permission of course director. S.

BIMD 513. Seminars in Biomedical Science. 1 Credit.

A series of presentations on original research conducted by UND faculty members as well as extramural leaders in academic and industrial research in the biomedical sciences. Students will participate through assigned reading and writing exercises related to the presentations.

BIMD 515. Steps to Success in Graduate School. 1 Credit.

A series of lectures and discussion sessions covering topics related to the development of skills and experience important for successful completion of graduate training and transition to post graduate training and employment. Students will examine a variety of issues including choosing an advisor and research topic, charting their course through graduate school, the importance of productivity, how to give a scientific presentation and write a scientific publication, applying for predoctoral grants, and planning for their careers.

BIMD 516. Responsible Conduct of Research. 1 Credit.

A series of lectures and discussion sessions covering topics related to responsible conduct in research. Students will examine a variety of issues including introduction to ethical decision making, the experience of conflict, laboratory practices, data management, reporting of research, conflict of interest, and compliance. Examples and case studies will be drawn primarily from the biomedical sciences.

PPT Courses

PPT 500. Principles of Physiology and Pharmacology. 6 Credits.

Graduate level survey course covering basic principles of human physiology and pharmacology. Material covered will include the physiology (how the body works) and the pharmacology (how drugs affect physiological functions) of the major organ systems. Covered also will be basic pharmacological principles including pharmacodynamics, pharmacokinetics and therapeutics. Teaching modalities used are designed to actively engage students in critical thinking and knowledge application. Prerequisite: BIMD 500 or consent of instructor.

PPT 503. Advanced Pharmacology or Physiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 505. Research Techniques. 1-3 Credits.

Prerequisite: Consent of instructor.

PPT 511. Biochemical and Molecular Mechanisms of Pharmacology. 3 Credits.

Fundamental concepts of pharmacology with emphasis on biochemical and molecular mechanisms. Prerequisites: BIMD 500 and PPT 500 or consent of instructor.

PPT 512. Special Topics in Pharmacology, Physiology and Therapeutics. 2 Credits.

An in-depth coverage of a particular topic chosen by the instructor. Prerequisite: Consent of instructor.

PPT 521. Seminar in Pharmacology, Physiology and Therapeutics. 1 Credit.

PPT 525. Advanced Renal Physiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 526. Advanced Respiratory Physiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 527. Advanced Neurophysiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 528. Advanced Endocrinology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 529. Adv Cardiovascular Physiology. 3 Credits.

Prerequisite: PPT 500 or consent of instructor.

PPT 530. Advanced Neurochemistry. 3 Credits.

This course is designed to introduce graduate students to the discipline of neurochemistry. This course builds on concepts introduced in PPT 500, with an emphasis on brain biochemical processes occurring in health and disease. Prerequisite: PPT 500 or consent of instructor.

PPT 535. Mechanisms of Neurodegenerative Disorders. 3 Credits.

This advanced course is designed for the graduate student who has a background in basic neuroscience. The course directive is to provide an overview of the more common neurodegenerative disorders and address the state of the field. Prerequisite: PPT 500 or consent of instructor.

PPT 540. Molecular Neuropharmacology. 3 Credits.

Prerequisite: BIMD 500 or PPT 500 or consent of instructor.

PPT 590. Readings in PPT. 1-4 Credits.

Prerequisite: Consent of instructor.

PPT 591. Research in PPT. 1-15 Credits.

PPT 996. Continuing Enrollment. 1-12 Credits.

Prerequisite: Consent of instructor.

PPT 998. Thesis. 1-9 Credits.

Prerequisite: Consent of instructor.

PPT 999. Dissertation. 1-12 Credits.

Prerequisite: Consent of instructor.

Office of the Registrar

Tel: 701.777.2711
1.800.CALL.UND
Fax: 701.777.2696

Twamley Hall Room 201
264 Centennial Drive Stop 8382
Grand Forks, ND 58202-8382