2014-2015 Catalog

Microbiology and Immunology

http://www.med.und.edu/microbiology/degrees.cfm

FACULTY: Bradley (Chair), Brissette, Flower (Graduate Director), Hill, Melvold (Emeritus), Mishra, Nilles and Sharma

Degrees Granted: Master of Science (M.S.), Doctor of Philosophy (Ph.D.) and Ph.D./M.D.

The four graduate programs at the University of North Dakota School of Medicine and Health Sciences are in the process of creating a combined, integrated, and multi-disciplinary program in Biomedical Sciences.  We anticipate that students entering the Microbiology and Immunology program in Fall 2014 will follow the newly developed curriculum and will become a part of the Biomedical Sciences Graduate Program.  Students previously enrolled in the Microbiology and Immunology program will have the option of completing their degree under existing requirements or transferring to the Biomedical Sciences Program.  Pending NDUS approval, information on the Biomedical Sciences Graduate Program and the course offering will be available after July 1, 2014 at the following web site:  med.und.edu/basic-sciences/bimd.

The Department of Microbiology and Immunology offers graduate programs leading to the M.S., Ph.D., and PhD/MD degrees. Graduate study is available in a number of subdisciplines including cell biology, pathogenic microbiology, genetics, immunology, immunogenetics, autoimmunity, microbial physiology, molecular biology, and virology. The goals of the program are to provide scientific training and experience for careers in research and teaching in universities, clinical and research laboratories and in fields of related employment. Additional background is available in disciplines such as biochemistry, computer sciences, statistics and electron microscopy in other departments in the School of Medicine and the University.

Core requirements for M.S. and Ph.D. degrees include courses in biochemistry, microbiology, molecular biology, immunology, statistics and graduate seminars. For both the M.S. and Ph.D. degrees, students are expected to carry out original research suitable for publication in a professional journal.

Master’s degree candidates are required to write a thesis and defend their research in a final oral examination. Doctoral candidates are required to successfully complete both a written and oral comprehensive examination as well as to write a dissertation and defend their research in a final oral examination.

A new, modern science building and an adjacent bioinformation learning resources center which house the research laboratories, library and teaching facilities of the School of Medicine were constructed in 1994. These facilities provide a state-of-the-art environment for teaching and research. The Department of Microbiology and Immunology occupies the fourth floor of the research building. Other basic science departments in this facility include the Departments of Anatomy and Cell Biology, Biochemistry and Molecular Biology, and Pharmacology, Physiology and Therapeutics. Additional resources include the Department of Pathology, the Energy and Environmental Research Center, the USDA Human Nutrition Center and the Computer Center. The proximity of these departments and facilities provides the opportunity for cooperative and collaborative research and training in the basic sciences.

Details pertaining to admission requirements, degree requirements and courses offered can be found in the Degree section.

Master of Science (M.S.)

Mission Statement and Program Goals

The M.S. program in the Department of Microbiology and Immunology will provide students with formal classroom instruction, mentored training in laboratory research, and other educational experiences that will prepare them for further research training or for careers in scientific industrial, governmental and educational settings.

The M.S. program in the Department of Microbiology and Immunology will provide students with formal classroom instruction, mentored training in laboratory research, and other educational experiences that will prepare them for further research training or for careers in scientific industrial, governmental and educational settings. Graduate study is available in a number of subdisciplines including host-pathogen interactions, pathogenic microbiology, immunology, vaccines and immunotherapies, microbial physiology and genetics, and molecular biology.

Goal 1: Students will demonstrate an appropriate knowledge base with respect to biomedical science, and to the fields of microbiology and immunology in particular. Students will demonstrate a thorough knowledge base of the field in which their research project is based.

Goal 2: Students will demonstrate the ability to analyze published scientific data.

Goal 3: Students will demonstrate the ability to present and defend their ideas, findings and analyses in written form and oral form.

Doctor of Philosophy (Ph.D.)

Mission Statement and Program Goals

The Ph.D. program in the Department of Microbiology and Immunology will provide students with formal classroom instruction, mentored training in laboratory research, and other educational experiences that will prepare them for advanced post-doctoral training and careers as independent biomedical scientists.

The Ph.D. program in the Department of Microbiology and Immunology will provide students with formal classroom instruction, mentored training in laboratory research, and other educational experiences that will prepare them for advanced post-doctoral training and careers as independent biomedical scientists. Graduate study is available in a number of subdisciplines including host-pathogen interactions, pathogenic microbiology, immunology, vaccines and immunotherapies, microbial physiology and genetics, and molecular biology.

Goal 1: Students will demonstrate an appropriate knowledge base with respect to biomedical science, and to the fields of microbiology and immunology in particular. Students will demonstrate a thorough knowledge base of the field in which their research project is based.

Goal 2: Students will demonstrate the ability to critically evaluate scientific data.

Goal 3: Students will learn to formulate and test hypotheses and to design informative and properly controlled experiments to test those hypotheses.

Goal 4: Students will demonstrate the ability to present, defend, and publish their ideas, findings, data, and analyses in written and oral form.


 

Master of Science (M.S.)

Admission Requirements

Applications for admission are accepted throughout the year. However, priority will be given to applications received by February 15 for Fall admission as awarding of financial aid for the next academic year is decided in March and early April.

The applicant must meet the School of Graduate Studies’ current minimum general admission requirements as published in the graduate catalog.

  1. Bachelor’s degree from an accredited institution and good academic record in the sciences.
  2. A minimum grade point average of 3.0 on a 4.0 scale.
  3. The Graduate Record Examination General Test.
  4. A course in Microbiology and a background in chemistry, preferably through organic chemistry, are recommended.
  5. Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.

Degree Requirements

Students seeking the Master of Science degree at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Microbiology and Immunology Department.

  1. A minimum of 30 credit hours including research and thesis.
  2. A grade of at least B in BIMD 500 Cellular and Molecular Foundations of Biomedical Science.
  3. Completion of BIMD 510 Basic Biomedical Statistics, BIMD 513 Seminars in Biomedical Science and BIMD 516 Responsible Conduct of Research.
  4. Completion of MBIO 513 Research Tools.
  5. Completions of one credit each of MBIO 507 Seminar in Microbiology and MBIO 511 Microbiology and Immunology Literature.
  6. Completion of MBIO 509 Immunology.
  7. Completion of two of the following (4 credits):
    MBIO 501Molecular Virology2
    MBIO 504Microbial Physiology2
    MBIO 508Microbial Pathogenesis2
    MBIO 512Microbial Genetics2
    MBIO 519Advanced Immunology2
    MBIO 591Special Problems in Microbiology1-6
  8. An overall GPA of at least 3.0.
  9. An acceptable thesis (4 credits minimum).
  10. Minimum course requirements as follows:
    BIMD 500Cellular and Molecular Foundations of Biomedical Science6
    BIMD 510Basic Biomedical Statistics2
    BIMD 513Seminars in Biomedical Science1
    BIMD 516Responsible Conduct of Research1
    MBIO 507Seminar in Microbiology1
    MBIO 509Immunology3
    MBIO 511Microbiology and Immunology Literature1
    MBIO 513Research Tools2
    MBIO 590
      & MBIO 998
    Research in Microbiology
       and Thesis
    4-9
    Select two of the following:4
    Molecular Virology
    Microbial Physiology
    Microbial Pathogenesis
    Microbial Genetics
    Advanced Immunology
    Special Problems in Microbiology
    Total Credits25-30

 

Doctor of Philosophy (Ph.D.)

Admission Requirements

The applicant must meet the School of Graduate Studies’ current minimum general admission requirements as published in the graduate catalog.

  1. Bachelor’s degree from an accredited institution and good academic record in the sciences.
  2. A minimum grade point average of 3.0 on a 4.0 scale.
  3. The Graduate Record Examination Test.
  4. A course in Microbiology and a background in chemistry, preferably through organic chemistry, are recommended.

Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.

Degree Requirements

Students seeking the Doctor of Philosphy degree at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Microbiology and Immunology Department.

  1. A minimum of 90 credit hours including research and dissertation.
  2. A grade of at least B in BIMD 500 Cellular and Molecular Foundations of Biomedical Science.
  3. Completion of BIMD 510 Basic Biomedical Statistics, BIMD 513 Seminars in Biomedical Science and BIMD 516 Responsible Conduct of Research.
  4. Completion of MBIO 513 Research Tools.
  5. Completions of one credit each of MBIO 507 Seminar in Microbiology and MBIO 511 Microbiology and Immunology Literature.
  6. Completion of MBIO 509 Immunology.
  7. Completion of four of the following (8 credits):
    MBIO 501Molecular Virology2
    MBIO 504Microbial Physiology2
    MBIO 508Microbial Pathogenesis2
    MBIO 512Microbial Genetics2
    MBIO 519Advanced Immunology2
    MBIO 591Special Problems in Microbiology1-6
  8. An overall GPA of at least 3.0.
  9. An acceptable dissertation.
  10. Minimum course requirements as follows:
    BIMD 500Cellular and Molecular Foundations of Biomedical Science6
    BIMD 510Basic Biomedical Statistics2
    BIMD 513Seminars in Biomedical Science1
    BIMD 516Responsible Conduct of Research1
    MBIO 507Seminar in Microbiology1
    MBIO 509Immunology3
    MBIO 511Microbiology and Immunology Literature1
    MBIO 513Research Tools2
    MBIO 590
      & MBIO 999
    Research in Microbiology
       and Dissertation (MBIO 590: up to 59 cr)
    65
    Select four of the following:8
    Molecular Virology
    Microbial Physiology
    Microbial Pathogenesis
    Microbial Genetics
    Advanced Immunology
    Special Problems in Microbiology
    Total Credits90

 

Combined Ph.D./M.D.

Through the cooperation of the School of Graduate Studies and the School of Medicine, students may concurrently pursue the Doctor of Philosophy degree in a medical science field (Anatomy and Cell Biology, Biochemistry and Molecular Biology, Microbiology and Immunology, Pharmacology, Physiology, and Therapeutics) and the Doctor of Medicine degree. The minimum time required to complete the joint program is six years of full-time academic study.

Students interested in the joint M.D./Ph.D. program should first obtain admission to the School of Medicine and Health Sciences to the M.D. program, following the normal application process and meeting the selection criteria. A student admitted to the M.D program may apply to the School of Graduate Studies as soon as he/she has selected a graduate program, which may occur before matriculation in Medical School but not later than the end of the first year of Medical School.

Final admission requirements for the M.D./Ph.D. program include:

  1. Satisfactory performance in the first two years of the medical education curriculum with passing scores on all required assessment tools.
  2. Successful completion of the USMLE Step 1 examination.
  3. Satisfactory scores achieved on General and Subject GRE examination or MCAT scores.
  4. All other UND School of Graduate Studies admission requirements listed in the UND Academic Catalog.

If admission to a Ph.D. program is granted, the student should apply to the School of Medicine and Health Sciences Student Performance and Recognition Committee for a “modification of original program” which will allow the student to pursue the M.D. degree and Ph.D. degree concurrently. The student also must request the Office of Student Affairs to certify to the School of Graduate Studies his/her satisfactory completion of the first two years of the M.D. program.

Students are expected to complete the following general requirements for the Ph.D. degree in a medical science field.:

  1. Performance of original research of a quality suitable for publication in refereed, professional journals.
  2. Pass final examination which includes preparation and oral defense of a satisfactory dissertaion.
  3. Completion of and .
  4. A minimum of 90 credit hours, including research and dissertation.
  5. Successful completion of a scholarly tool (Note: May be specified by a department.)
  6. Completion of the first two years of the medical education curriculum, transferred as 44 credits toward the Ph.D.

BIMD Courses

BIMD 500. Cellular and Molecular Foundations of Biomedical Science. 6 Credits.

A series of lectures and discussion groups with emphasis on interrelated themes in basic biochemistry, cell biology and molecular biology. Lectures will include current and emerging areas of research, while discussion will center on methods, techniques and expansion of lecture topics. Prerequisites: (a) a year of organic chemistry or (b) one semester of organic chemistry plus a course in either biochemistry or cell biology, or (c) permission of the course director. F.

BIMD 510. Basic Biomedical Statistics. 2 Credits.

A series of lectures, demonstrations and exercises to provide students with the basic rationales for the use of statistics in the assessment of biomedical data and a selected set of the most common and useful statistical tests. Prerequisite: BIMD 500 or permission of course director. S.

BIMD 513. Seminars in Biomedical Science. 1 Credit.

A series of presentations on original research conducted by UND faculty members as well as extramural leaders in academic and industrial research in the biomedical sciences. Students will participate through assigned reading and writing exercises related to the presentations.

BIMD 515. Steps to Success in Graduate School. 1 Credit.

A series of lectures and discussion sessions covering topics related to the development of skills and experience important for successful completion of graduate training and transition to post graduate training and employment. Students will examine a variety of issues including choosing an advisor and research topic, charting their course through graduate school, the importance of productivity, how to give a scientific presentation and write a scientific publication, applying for predoctoral grants, and planning for their careers.

BIMD 516. Responsible Conduct of Research. 1 Credit.

A series of lectures and discussion sessions covering topics related to responsible conduct in research. Students will examine a variety of issues including introduction to ethical decision making, the experience of conflict, laboratory practices, data management, reporting of research, conflict of interest, and compliance. Examples and case studies will be drawn primarily from the biomedical sciences.

MBIO Courses

MBIO 501.* Molecular Virology. 2 Credits.

Genetics and molecular biology of animal and bacterial viruses, with emphasis on viral-host interactions, viral replication, and viral gene expression. Prerequisites: Microbiology and biochemistry and/or consent of instructor. S, odd years.

MBIO 504.* Microbial Physiology. 2 Credits.

The course will investigate the physiology of the bacterial cell as it pertains to the processes carried out by the cell. Topics will include basic cell structure, motility, chemotaxis, uptake of nutrients, metabolism, gene regulation, evolution, cell division, differentiation, and pathogenesis. The integration of various cellular functions to sustain the living cell will be emphasized. The course will be based largely on current literature and will involve class discussions of assigned topics. In addition to gaining an understanding of the bacterial cell, students will learn to read primary literature critically and the principles involved in writing a scientific paper. Discussions will be based upon readings from the current literature. Prerequisites: A basic course in microbiology and organic chemistry or biochemistry or consent of instructor. S, odd years.

MBIO 507. Seminar in Microbiology. 1 Credit.

F.

MBIO 508.* Microbial Pathogenesis. 2 Credits.

A detailed study of pathogenic microorganisms and the mechanisms by which they cause tissue and cell injury. Prerequisite: BIMD 500 or equivalent. S, even years.

MBIO 509. Immunology. 3 Credits.

An introduction to the fundamentals of immunology including immunochemistry, humoral and cellular response, hypersensitivity, immunodeficiency, immunogenetics, tolerance and immunodiagnosis. Prerequisite: BIMD 500 or equivalent. F.

MBIO 511. Microbiology and Immunology Literature. 1 Credit.

A series of reports of current scientific literature in Microbiology and Immunology. S.

MBIO 512.* Microbial Genetics. 2 Credits.

Genetic mechanisms in microorganisms, mutagenesis, fine structure of genetic material, genetic engineering. Selected Readings. Prerequisites :Basic courses in genetics and microbiology or biochemistry and/or consent of instructor. S, even years.

MBIO 513. Research Tools. 2 Credits.

Orientation to research and laboratory safety. The theory and application of modern laboratory techniques include tissue culture, cell fractionation, enzyme assay, immunization procedures, bacterial growth curves, photomicrography, strain construction, genetic engineering, gel electrophoresis, enzyme immunoassay, and western blot techniques are presented. F.

MBIO 515. Advanced Topics. 2 Credits.

A series of topics in microbiology and immunology presented on an episodic basis. The topics may vary, but are expected to include: (A) Immunology, (B) Infectious Diseases, and (C) Molecular Biology. Prerequisite: Previous basic course in the area to be covered.

MBIO 519. Advanced Immunology. 2 Credits.

An advanced discussion of the genesis and regulation of innate and adaptive immune responses. Selected readings. Prerequisite: MBIO 509 or equivalent, or permission of instructor. S.

MBIO 590. Research in Microbiology. 2-6 Credits.

Advanced problems in microbiology and related fields. Hours arranged.

MBIO 591. Special Problems in Microbiology. 1-6 Credits.

Short-term research projects.

MBIO 996. Continuing Enrollment. 1-12 Credits.

MBIO 997. Independent Study. 2 Credits.

MBIO 998. Thesis. 1-8 Credits.

MBIO 999. Dissertation. 1-15 Credits.

* Courses marked with an (*) are offered in alternate years only.

Office of the Registrar

Tel: 701.777.2711
1.800.CALL.UND
Fax: 701.777.2696

Twamley Hall Room 201
264 Centennial Drive Stop 8382
Grand Forks, ND 58202-8382