2016-2017 Catalog

Microbiology and Immunology

The Microbiology & Immunology program is no longer accepting applications.

Please go to the Biomedical Sciences page at: 

 http://und-public.courseleaf.com/graduateacademicinformation/departmentalcoursesprograms/biomedicalsciences/

The four graduate programs (Anatomy & Cell Biology, Biochemistry & Molecular Biology, Microbiology & Immunology, and Pharmacology, Physiology & Therapeutics) at the University of North Dakota School of Medicine and Health Sciences are now combined into an integrated, multi-disciplinary program in Biomedical Sciences. Students that entered the programs in fall 2014 will follow the newly developed curriculum and will become a part of the Biomedical Sciences graduate program. Students who enrolled in the four programs previous to fall 2014 will have the option of either completing degree requirements for the program in which they enrolled (found in previous UND Academic Catalogs) or transferring to and completing degree requirements for the Biomedical Sciences graduate program.

 

Master of Science (M.S.)

Admission Requirements

Applications for admission are accepted throughout the year. However, priority will be given to applications received by February 15 for Fall admission as awarding of financial aid for the next academic year is decided in March and early April.

The applicant must meet the School of Graduate Studies’ current minimum general admission requirements as published in the graduate catalog.

  1. Bachelor’s degree from an accredited institution and good academic record in the sciences.
  2. A minimum grade point average of 3.0 on a 4.0 scale.
  3. The Graduate Record Examination General Test.
  4. A course in Microbiology and a background in chemistry, preferably through organic chemistry, are recommended.
  5. Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.

Degree Requirements

Students seeking the Master of Science degree at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Microbiology and Immunology Department.

  1. A minimum of 30 credit hours including research and thesis.
  2. A grade of at least B in BIMD 500 Cellular and Molecular Foundations of Biomedical Science.
  3. Completion of BIMD 510 Basic Biomedical Statistics, BIMD 513 Seminars in Biomedical Science and BIMD 516 Responsible Conduct of Research.
  4. Completion of MBIO 513 Research Tools.
  5. Completions of one credit each of MBIO 507 Seminar in Microbiology and MBIO 511 Microbiology and Immunology Literature.
  6. Completion of MBIO 509 Immunology.
  7. Completion of two of the following (4 credits):
    MBIO 501Molecular Virology2
    MBIO 504Microbial Physiology2
    MBIO 508Microbial Pathogenesis2
    MBIO 512Microbial Genetics2
    MBIO 519Advanced Immunology2
    MBIO 591Special Problems in Microbiology1-6
  8. An overall GPA of at least 3.0.
  9. An acceptable thesis (4 credits minimum).
  10. Minimum course requirements as follows:
    BIMD 500Cellular and Molecular Foundations of Biomedical Science6
    BIMD 510Basic Biomedical Statistics2
    BIMD 513Seminars in Biomedical Science1
    BIMD 516Responsible Conduct of Research1
    MBIO 507Seminar in Microbiology1
    MBIO 509Immunology3
    MBIO 511Microbiology and Immunology Literature1
    MBIO 513Research Tools2
    MBIO 590
    MBIO 998
    Research in Microbiology
    and Thesis
    4-9
    Select two of the following:4
    Molecular Virology
    Microbial Physiology
    Microbial Pathogenesis
    Microbial Genetics
    Advanced Immunology
    Special Problems in Microbiology
    Total Credits25-30

 

Doctor of Philosophy (Ph.D.)

Admission Requirements

The applicant must meet the School of Graduate Studies’ current minimum general admission requirements as published in the graduate catalog.

  1. Bachelor’s degree from an accredited institution and good academic record in the sciences.
  2. A minimum grade point average of 3.0 on a 4.0 scale.
  3. The Graduate Record Examination Test.
  4. A course in Microbiology and a background in chemistry, preferably through organic chemistry, are recommended.

Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.

Degree Requirements

Students seeking the Doctor of Philosphy degree at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Microbiology and Immunology Department.

  1. A minimum of 90 credit hours including research and dissertation.
  2. A grade of at least B in BIMD 500 Cellular and Molecular Foundations of Biomedical Science.
  3. Completion of BIMD 510 Basic Biomedical Statistics, BIMD 513 Seminars in Biomedical Science and BIMD 516 Responsible Conduct of Research.
  4. Completion of MBIO 513 Research Tools.
  5. Completions of one credit each of MBIO 507 Seminar in Microbiology and MBIO 511 Microbiology and Immunology Literature.
  6. Completion of MBIO 509 Immunology.
  7. Completion of four of the following (8 credits):
    MBIO 501Molecular Virology2
    MBIO 504Microbial Physiology2
    MBIO 508Microbial Pathogenesis2
    MBIO 512Microbial Genetics2
    MBIO 519Advanced Immunology2
    MBIO 591Special Problems in Microbiology1-6
  8. An overall GPA of at least 3.0.
  9. An acceptable dissertation.
  10. Minimum course requirements as follows:
    BIMD 500Cellular and Molecular Foundations of Biomedical Science6
    BIMD 510Basic Biomedical Statistics2
    BIMD 513Seminars in Biomedical Science1
    BIMD 516Responsible Conduct of Research1
    MBIO 507Seminar in Microbiology1
    MBIO 509Immunology3
    MBIO 511Microbiology and Immunology Literature1
    MBIO 513Research Tools2
    MBIO 590
    MBIO 999
    Research in Microbiology
    and Dissertation (MBIO 590: up to 59 cr)
    65
    Select four of the following:8
    Molecular Virology
    Microbial Physiology
    Microbial Pathogenesis
    Microbial Genetics
    Advanced Immunology
    Special Problems in Microbiology
    Total Credits90

 

Combined Ph.D./M.D.

Through the cooperation of the School of Graduate Studies and the School of Medicine, students may concurrently pursue the Doctor of Philosophy degree in a medical science field (Anatomy and Cell Biology, Biochemistry and Molecular Biology, Microbiology and Immunology, Pharmacology, Physiology, and Therapeutics) and the Doctor of Medicine degree. The minimum time required to complete the joint program is six years of full-time academic study.

Students interested in the joint M.D./Ph.D. program should first obtain admission to the School of Medicine and Health Sciences to the M.D. program, following the normal application process and meeting the selection criteria. A student admitted to the M.D program may apply to the School of Graduate Studies as soon as he/she has selected a graduate program, which may occur before matriculation in Medical School but not later than the end of the first year of Medical School.

Final admission requirements for the M.D./Ph.D. program include:

  1. Satisfactory performance in the first two years of the medical education curriculum with passing scores on all required assessment tools.
  2. Successful completion of the USMLE Step 1 examination.
  3. Satisfactory scores achieved on General and Subject GRE examination or MCAT scores.
  4. All other UND School of Graduate Studies admission requirements listed in the UND Academic Catalog.

If admission to a Ph.D. program is granted, the student should apply to the School of Medicine and Health Sciences Student Performance and Recognition Committee for a “modification of original program” which will allow the student to pursue the M.D. degree and Ph.D. degree concurrently. The student also must request the Office of Student Affairs to certify to the School of Graduate Studies his/her satisfactory completion of the first two years of the M.D. program.

Students are expected to complete the following general requirements for the Ph.D. degree in a medical science field.:

  1. Performance of original research of a quality suitable for publication in refereed, professional journals.
  2. Pass final examination which includes preparation and oral defense of a satisfactory dissertaion.
  3. Completion of and .
  4. A minimum of 90 credit hours, including research and dissertation.
  5. Successful completion of a scholarly tool (Note: May be specified by a department.)
  6. Completion of the first two years of the medical education curriculum, transferred as 44 credits toward the Ph.D.

BIMD Courses

BIMD 501. Scientific Discovery I. 6 Credits.

A problem based course in which students will address a set of biomedical research scenarios that have been designed so that students will acquire skills in critical thinking, finding, interpreting, and analyzing scientific literature, developing hypothesis-driven questions, proposing and designing experiments, and communicating scientific outcomes orally and in written format. F.

BIMD 502. Scientific Discovery II. 6 Credits.

A problem based course in which students will address a set of biomedical research scenarios that have been designed so that students will advance their skills in critical thinking, finding, interpreting, and analyzing scientific literature, developing hypothesis-driven questions, proposing and designing experiments, and communicating scientific outcomes orally and in written format. This course is a continuation and advancement of BIMD 501. Prerequisite: BIMD 501. S.

BIMD 510. Basic Biomedical Statistics. 2 Credits.

A series of lectures, demonstrations and exercises to provide students with the basic rationales for the use of statistics in the assessment of biomedical data and a selected set of the most common and useful statistical tests. Prerequisite: BIMD 500 or permission of course director. S.

BIMD 513. Seminars in Biomedical Science. 1 Credit.

A series of presentations on original research conducted by UND faculty members as well as extramural leaders in academic and industrial research in the biomedical sciences. Students will participate through assigned reading and writing exercises related to the presentations.

BIMD 516. Responsible Conduct of Research. 2 Credits.

A series of lectures and discussion sessions covering topics related to responsible conduct in research. Students will examine a variety of issues including introduction to ethical decision making, the experience of conflict, laboratory practices, data management, reporting of research, conflict of interest, and compliance. Examples and case studies will be drawn primarily from the biomedical sciences. F.

BIMD 518. Grant Writing. 2 Credits.

This is an advanced graduate grant writing and oral presentation course. The objectives of this course are to challenge students: (1) to critically evaluate their own research in an effort to clearly define the significance and innovation of their project, (2) to begin to develop novel ideas based on their research efforts that have the potential to significantly impact their field of study, and (3) to prepare students to present these ideas orally and in writing in a manner that is both logical and convincing. Prerequisites: BIMD 501 and BIMD 502, or consent of instructor. F.

BIMD 520. Principles of Neuroanatomy. 2 Credits.

In this course students will learn the fundamental principles of neuroscience, particularly gross and cellular anatomy, development and systems physiology of the nervous system. Behavioral, cognitive and clinical manifestations of abnormal neural functions will also be addressed. Prerequisite: BIMD 502 or permission of instructor. F.

BIMD 521. Neurophysiology. 2 Credits.

This course is designed to introduce students to the electrical properties of neuronal membranes. The course is organized to first provide a brief review of the basic properties of semi-permeable membranes. The electrical and biochemistry principles that apply to neuronal membranes are discussed. Prerequisite: BIMD 502 or consent of instructor. F.

BIMD 522. Principles of Neuropharmacology. 2 Credits.

This course is designed to introduce students to the latest developments in molecular neuropharmacology. The course directive is to provide an up-to-date foundation for clinical neuroscience by emphasizing a comprehensive molecular and cellular approach to the effects of drugs on the nervous system. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 523. Neurochemical Basis of the Nervous System. 2 Credits.

This course is designed to introduce students to fundamental concepts of brain metabolism and neurochemical signaling. It emphasizes recent advances in understanding brain biochemical processes and molecular mechanisms occurring in health and disease. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 524. Neurodegenerative Diseases and Pathophysiology. 2 Credits.

This course exposes students to diverse neurodegenerative diseases and nervous system pathophysiology. The emphasis is on mechanistic understanding of the most recent advances in the field. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 525. Readings in Neuroscience. 1-4 Credits.

A supervised readings course on topics of mutual interest to the student and a faculty member. Prerequisite: BIMD 502 or consent of instructor. Repeatable to 4 credits. On demand.

BIMD 530. Components of the Immune System. 2 Credits.

Have you ever wondered why you don't get sick every time you breathe air which can carry as many as 2000 different kinds of microbes on any given day? Or what keeps your defense system from attacking your own cells but can get rid of most invaders without you even noticing? This is the amazing task of your fascinating immune system! This course will provide an overview of cellular and molecular components of mammalian immune system and their function. The students will learn how these components are derived and how they interact and communicate with each other to coordinate a response to pathological insults in order to protect the human body. Prerequisite: BIMD 502 or consent of instructor. F.

BIMD 531. Components of Microbial Pathogenesis. 2 Credits.

The objective of the course is to provide students with a background in the mechanisms of microbial pathogenesis. Students will learn basic principles of host-parasite interactions. Paradigms of host-parasite interactions will be illustrated by studying, at the molecular and cellular levels, specific infectious diseases and the agents that cause them. Prerequisite: BIMD 502 or consent of instructor. F.

BIMD 532. Microbial Gene Regulation. 1 Credit.

This course will provide an understanding of genetic regulation in bacteria. Classic pathways will be examined as paradigms of regulatory circuits. These examples will be expanded to learn how bacteria exploit host cells as well as the use of bacterial regulatory circuits in modern molecular biology. S.

BIMD 533. Microbial Membranes and Transport. 1 Credit.

This course will explore bacterial membranes with particular emphasis on generation of energy and transport of molecules across the membranes. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 534. Microbial Cell Structure and Function. 1 Credit.

Microbial cells have unique structures that relate their functions. Students completing this course will have an understanding of how prokaryotic and eukaryotic organisms differ and how different structures can be used to obtain similar functions. They will understand how microbial structures influence interactions between microbes and between microbes and eukaryotic organisms. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 535. Bacterial Host: Pathogen Interactions. 1 Credit.

The objective of the course is to provide students with a background in the fundamental aspects that occur at the bacterial: host interface. Students will learn the interplay between bacterial virulence factors, strategies used to evade host defenses, and host responses to infection. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 536. Molecular Biology and Pathogenesis of Viruses. 1 Credit.

This course will cover the structure, replication, and pathogenesis of human RNA and DNA viruses, the host immune response to viral infection and the strategies employed by viruses to escape immune detection and elimination. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 537. Host-Pathogen Interactions involving Eukaryotic Microbes (Parasites/Fungi). 1 Credit.

Eukaryotic microbe infections have a devastating impact on global health and economic development as they infect over one third of the world's population and cause acute and chronic pathologies. Furthermore, macroscopic parasites (helminths/ worms) are master regulators of host inflammatory response and hence reduce the immune response to coinfections and negatively affect the success of vaccination programs against many other pathogens. In contrast, it has been proposed that the rise in autoimmune diseases in the developed world could be a direct result of the successful complete elimination of parasitic helminths in these communities. Thus, the purpose of this course is to provide a basic knowledge of the clinically important eukaryotic microbe pathogens and the immune response associated with their infections. A series of lectures will cover course components; a) basic introduction to protozoa, helminth, and fungi, and b) basic knowledge of the immune response and its involvement in parasitic/ fungal infections. An effort has been made to increase clinical relevance and problem-solving skills through a team-learning exercise involving quiz and paper presentations. S.

BIMD 538. Immunological Disorders. 1 Credit.

This course will include discussion of cellular and molecular immunopathologies leading to autoimmune diseases, and primary and secondary immunodeficiencies; and the role of the immune system in tumorigeneses and transplantation, as well as various methods of modification of the immune response. Prerequisite: BIMD 502 or consent of instructor. S.

BIMD 539. Readings in Microbiology and Immunology. 1-4 Credits.

A supervised readings course on topics of mutual interest to the student and a faculty member. Prerequisite: BIMD 502 or consent of instructor. Repeatable to 4 credits. On demand.

BIMD 590. Research. 1-12 Credits.

The course allows research in pertinent problems in various aspects of biomedical sciences. Repeatable. F,S,SS.

BIMD 591. Advanced Topics in Biomedical Sciences. 1-3 Credits.

A series of lectures, discussions and/or laboratory experiences developed around a specific topic in the biomedical sciences. Repeatable as topics vary. Prerequisite: BIMD 502 or consent of instructor. Repeatable to 6 credits. On demand.

BIMD 998. Thesis. 1-6 Credits.

Completion of thesis required for M.S. Repeatable to 6 credits. F,S,SS.

BIMD 999. Dissertation. 1-12 Credits.

Completion of dissertation required for Ph.D. Repeatable to 12 credits. F,S,SS.

MBIO Courses

MBIO 507. Seminar in Microbiology. 1 Credit.

S/U grading. F.

MBIO 511. Microbiology and Immunology Literature. 1 Credit.

A series of reports of current scientific literature in Microbiology and Immunology. S/U grading. S.

MBIO 513. Research Tools. 2 Credits.

Orientation to research and laboratory safety. The theory and application of modern laboratory techniques include tissue culture, cell fractionation, enzyme assay, immunization procedures, bacterial growth curves, photomicrography, strain construction, genetic engineering, gel electrophoresis, enzyme immunoassay, and western blot techniques are presented. S/U grading. F.

MBIO 515. Advanced Topics. 2 Credits.

A series of topics in microbiology and immunology presented on an episodic basis. The topics may vary, but are expected to include: (A) Immunology, (B) Infectious Diseases, and (C) Molecular Biology. Prerequisite: Previous basic course in the area to be covered.

MBIO 590. Research in Microbiology. 2-6 Credits.

Advanced problems in microbiology and related fields. Hours arranged. Repeatable.

MBIO 591. Special Problems in Microbiology. 1-6 Credits.

Short-term research projects.

MBIO 996. Continuing Enrollment. 1-12 Credits.

Repeatable. S/U grading.

MBIO 997. Independent Study. 2 Credits.

MBIO 998. Thesis. 1-8 Credits.

Repeatable to 8 credits.

MBIO 999. Dissertation. 1-15 Credits.

Repeatable to 15 credits.

Office of the Registrar

Tel: 701.777.2711
1.800.CALL.UND
Fax: 701.777.2696

Twamley Hall Room 201
264 Centennial Drive Stop 8382
Grand Forks, ND 58202-8382