2014-2015 Catalog

Biochemistry and Molecular Biology

http://www.med.und/biochemistry/index.cfm

FACULTY: Dhasarathy, Foster, Milavetz, Ohm, Shabb, Singh, Sukalski, Vaughan, Wu (Graduate Director) and Xie

JOINT FACULTY: Garrett, D. Sens, M. Sens, Somji

Degrees Granted: Master of Science (M.S.), Doctor of Philosophy (Ph.D.) and Combined M.D./Ph.D.

The four graduate programs at the University of North Dakota School of Medicine and Health Sciences are in the process of creating a combined, integrated, and multi-disciplinary program in Biomedical Sciences.  We anticipate that students entering the Biochemistry and Molecular Biology program in Fall 2014 will follow the newly developed curriculum and will become a part of the Biomedical Sciences Graduate Program.  Students previously enrolled in the Biochemistry and Molecular Biology program will have the option of completing their degree under existing requirements or transferring to the Biomedical Sciences Program.  Pending NDUS approval, information on the Biomedical Sciences Graduate Program and the course offerings will be available after July 1, 2014 at the following web site:  med.und.edu/basic-sciences/bimd. 

The department of Biochemistry and Molecular Biology offers graduate programs leading to the M.S. and, Ph.D., degrees. All programs are research-oriented and students begin research work during their first year. These graduate programs prepare scholars for a variety of careers including academic teaching and research, and research associated careers in various governmental, industrial, and private research laboratories.

The department is housed within the Edwin C. James Medical Research Facility of the University of North Dakota School of Medicine and Health Sciences. Research is conducted in the areas related to cell signaling, epigenetics, protein/protein interactions, and proteomics. Joint faculty from the Department of Pathology (UND School of Medicine and Health Sciences) provides additional research opportunities for graduate students in our program in the areas of heavy metal toxicology, tumorogensis and cancer biomarkers.

Details pertaining to admission requirements, degree requirements and courses offered can be found in the Degree section.

Master of Science (M.S.)

Mission Statement and Program Goals

The masters program in the Department of Biochemistry and Molecular Biology will provide formal classroom instruction and mentored research experiences that enable and encourage students to become competent scientists. The M.S. graduate will be competitive for a broad scope of career paths. These include but are not limited to pursuing a terminal degree, working in a research setting, or other science-related career options.

Goal 1: M.S. graduates will have a foundational knowledge of biochemistry and molecular biology.

Goal 2: M.S. graduates will have the ability to conduct meaningful scientific inquiry.

Goal 3: M.S. graduates will possess communication skills necessary to relate the results of their scientific queries clearly to others.

Goal 4: M.S. graduates will demonstrate professional and ethical scientific behavior, including a commitment to continual professional development.

Doctor of Philosophy (Ph.D.)

Mission Statement and Program Goals

The Ph.D. program in the Department of Biochemistry and Molecular Biology will provide formal classroom instruction and mentored research experiences that enable and encourage students to become competent, creative, and independent biomedical scientist.

Goal 1: Ph.D. graduates will have a foundational knowledge of biochemistry and molecular biology.

Goal 2: Ph.D. graduates will have the ability to conduct meaningful scientific inquiry.

Goal 3: Ph.D. graduates will possess communication skills necessary to relate the results of their scientific queries clearly and convincingly to others.

Goal 4: Ph.D. graduates will demonstrate professional and ethical scientific behavior, including a commitment to continual professional development.

 

Master of Science (M.S.)

Admission Requirements

The applicant must meet the School of Graduate Studies’ current minimum general admission requirements as published in the graduate catalog.

  1. A four-year bachelor’s degree from a recognized college or university. For U.S. degrees, accreditation must be by one of the six regional accrediting associations.
  2. Minimally, the applicant successfully will have completed the following coursework:
    • General biology or zoology (one year sequence)
    • General chemistry (one year sequence)
    • Organic chemistry (minimum of 6 semester credits)
  3. Coursework in calculus, physics, and analytical chemistry, cell biology, molecular biology, biochemistry, and genetics is recommended.
  4. The general Graduate Record Examination is required.
  5. Satisfy the School of Graduate Studies’ English Language Proficiency requirements as published in the graduate catalog.

Degree Requirements

Students seeking the Master of Science degree through the Department of Biochemistry and Molecular Biology at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Department of Biochemistry and Molecular Biology.

  1. A minimum of 30 credit hours including research and thesis.
  2. At least one-half of the credits must be at or above the 500-level.
  3. A maximum of one-fourth (usually 8-9 semester credits) of the credit hours required for the degree may be transferred from another institution.
  4. A grade of “C” or better in BIMD 500 Cellular and Molecular Foundations of Biomedical Science and an overall GPA of at least 3.0.
  5. Preparation and oral defense of a satisfactory thesis.
  6. Required Courses:
  7. BIMD 500Cellular and Molecular Foundations of Biomedical Science6
    BIMD 510Basic Biomedical Statistics2
    BIMD 513Seminars in Biomedical Science1
    BMB 514Current Literature1
    BIMD 516Responsible Conduct of Research1
    BMB 521Seminar1
    BMB 533Advanced Topics3
    BMB 590Research11
    BMB 998Thesis4
    Total Credits30

 

Doctor of Philosophy (Ph.D.)

Admission Requirements

The applicant must meet the School of Graduate Studies’ current minimum general admission requirements as published in the graduate catalog.

  1. A four-year bachelor’s degree from a recognized college or university. For U.S. degrees, accreditation must be by one of the six regional accrediting associations.
  2. Minimally, the applicant successfully will have completed the following coursework:
    • General biology or zoology (one year sequence)
    • General chemistry (one year sequence)
    • Organic chemistry (minimum of 6 semester credits)
  3. Courses in calculus, physics, analytical chemistry, cell biology, molecular biology, biochemistry, and genetics are recommended.
  4. The general Graduate Record Examination is required.
  5. Satisfy the School of Graduate Studies’ English Language Proficiency requirements as listed in the graduate catalog.

A student who has begun the Master of Science Program in Biochemistry and Molecular Biology may transfer into the doctoral program and have work completed incorporated into the doctoral program if approved by the BMB graduate faculty and the Dean of the School of Graduate Studies. Students in the master’s program who wish to proceed toward the Ph.D. degree without obtaining an M.S. may request permission to do so after they meet the following requirements:

  1. Accumulation of a minimum of 19 graduate credits with a GPA of 3.5 or greater.
  2. Minimum cumulative GPA of 3.0 in:
  3. BIMD 500Cellular and Molecular Foundations of Biomedical Science6
    BIMD 510Basic Biomedical Statistics2
    BIMD 513Seminars in Biomedical Science1
    BIMD 515Steps to Success in Graduate School1
    BIMD 516Responsible Conduct of Research1
    BMB 533Advanced Topics (at least one credit)1
  4. A minimum of 4 credits of BMB 590 Research.

Degree Requirements

Students seeking the Doctor of Philosophy degree through the Department of Biochemistry and Molecular Biology at the University of North Dakota must satisfy all general requirements set forth by the School of Graduate Studies as well as particular requirements set forth by the Department of Biochemistry and Molecular Biology.

  1. Performance of original research of a quality suitable for publication in a refereed, professional journal and the preparation of a dissertation based thereon.
  2. A minimum of 90 credit hours, including research and dissertation.
  3. At least one-half of the credits must be at or above the 500-level.
  4. A maximum of one-fourth (usually eight-to-nine semester credits) of the credit hours required for the degree may be transferred from another institution.
  5. A grade of “B” or better in BIMD 500 Cellular and Molecular Foundations of Biomedical Science and an overall GPA of at least 3.0.
  6. Passing performance on oral and written comprehensive examinations covering the coursework in the major and related areas.
  7. Preparation and oral defense of a satisfactory dissertation.
  8. Required Courses:
  9. BIMD 500Cellular and Molecular Foundations of Biomedical Science6
    BIMD 510Basic Biomedical Statistics2
    BIMD 513Seminars in Biomedical Science1
    BMB 514Current Literature2
    BIMD 516Responsible Conduct of Research1
    BMB 521Seminar2
    BMB 533Advanced Topics6
    BMB 590Research51
    Electives (Outside of the Department of BMB)6
    BMB 999Dissertation (minimum)6
    A minimum of 7 more credits of coursework, research or dissertation7
    Total Credits90

 

Combined M.D./Ph.D.

Through the cooperation of the School of Graduate Studies and the School of Medicine, students may concurrently pursue the Doctor of Philosophy degree in a medical science field (Anatomy and Cell Biology, Biochemistry and Molecular Biology, Microbiology and Immunology, Pharmacology, Physiology and Therapeutics) and the Doctor of Medicine degree. The minimum time required to complete the joint program is six years of full-time academic study.

Students interested in the joint M.D./Ph.D. program should first obtain admission to the School of Medicine and Health Sciences to the M.D. degree program, following the normal application process and meeting the selection criteria. A student admitted to the M.D. program may apply to School of Graduate Studies as soon as he/she has selected a graduate program, which may occur before matriculation in Medical School but not later than the end of the first year of Medical School.

Final admission requirements for the M.D./Ph.D. program include:

  1. Satisfactory performance in the first two years of the medical education curriculum with passing scores on all required assessment tools.
  2. Successful completion of the USMLE Step 1 examination.
  3. Satisfactory scores achieved on General and Subject GRE examination or MCAT scores.
  4. All other UND School of Graduate Studies admission requirements listed in the UND Academic Catalog.

If admission to a Ph.D. program is granted, the student should apply to the School of Medicine and Health Sciences Student Performance and Recognition Committee for a “modification of original program,” which will allow the student to pursue the M.D. degree and Ph.D. degree concurrently. The student also must request the Office of Student Affairs to certify to the School of Graduate Studies his/her satisfactory completion of the first two years of the M.D. program.

Students are expected to complete the following general requirements for the Ph.D. degree in a medical science field:

  1. Performance of original research of a quality suitable for publication in refereed, professional journals.
  2. Pass final examination which includes preparation and oral defense of a satisfactory dissertation.
  3. Completion of .
  4. A minimum of 90 credit hours, including research and dissertation.
  5. Successful completion of a scholarly tool (Note: May be specified by a department.)
  6. Completion of the first two years of the medical education curriculum, transferred as 44 credits toward the Ph.D.

BIMD Courses

BIMD 500. Cellular and Molecular Foundations of Biomedical Science. 6 Credits.

A series of lectures and discussion groups with emphasis on interrelated themes in basic biochemistry, cell biology and molecular biology. Lectures will include current and emerging areas of research, while discussion will center on methods, techniques and expansion of lecture topics. Prerequisites: (a) a year of organic chemistry or (b) one semester of organic chemistry plus a course in either biochemistry or cell biology, or (c) permission of the course director. F.

BIMD 510. Basic Biomedical Statistics. 2 Credits.

A series of lectures, demonstrations and exercises to provide students with the basic rationales for the use of statistics in the assessment of biomedical data and a selected set of the most common and useful statistical tests. Prerequisite: BIMD 500 or permission of course director. S.

BIMD 513. Seminars in Biomedical Science. 1 Credit.

A series of presentations on original research conducted by UND faculty members as well as extramural leaders in academic and industrial research in the biomedical sciences. Students will participate through assigned reading and writing exercises related to the presentations.

BIMD 515. Steps to Success in Graduate School. 1 Credit.

A series of lectures and discussion sessions covering topics related to the development of skills and experience important for successful completion of graduate training and transition to post graduate training and employment. Students will examine a variety of issues including choosing an advisor and research topic, charting their course through graduate school, the importance of productivity, how to give a scientific presentation and write a scientific publication, applying for predoctoral grants, and planning for their careers.

BIMD 516. Responsible Conduct of Research. 1 Credit.

A series of lectures and discussion sessions covering topics related to responsible conduct in research. Students will examine a variety of issues including introduction to ethical decision making, the experience of conflict, laboratory practices, data management, reporting of research, conflict of interest, and compliance. Examples and case studies will be drawn primarily from the biomedical sciences.

BMB Courses

BMB 514. Current Literature. 1 Credit.

Students of the department rotate in leading informal reviews, analyses, and the discussions of research papers selected from current journals in the areas of biochemistry and molecular biology. Prerequisite: BIMD 500 or consent of instructor.

BMB 521. Seminar. 1 Credit.

Students present topics in biochemistry and molecular biology based on reviews of the current literature. Each presentation is followed by a discussion of the topic by the faculty and students of the department. Prerequisite: BIMD 500 or consent of instructor.

BMB 533. Advanced Topics. 1 Credit.

The purpose of this course is to provide an in-depth exploration of selected areas of protein structure and function, metabolism, regulation of cell functions, proteomics, recombinant DNA technology, eukaryotic nucleic acid metabolism, and gene expression with the intent of complementing and extending the knowledge base gained in BIMD 500. Extensive independent learning is expected. Prerequisites: BIMD 500; alternatively, BMB 301 or equivalent and permission of instructor.

BMB 540. Special Topics. 1-3 Credits.

Discussion of a topic in biochemistry and/or molecular biology of current interest to faculty and students. Prerequisites: BIMD 500 or consent of instructor.

BMB 590. Research. 1-12 Credits.

The assignments deal with pertinent research problems in various aspects of biochemistry and molecular biology.

BMB 594. Special Problems in Biochemistry and Molecular Biology. 1-6 Credits.

The student in consultation with a faculty member of the department undertakes a laboratory research project. Prerequisite: Consent of instructor.

BMB 595. Readings in Biochemistry and Molecular Biology. 1-3 Credits.

Selected readings and library research in an area of mutual interest to the student and a faculty member of the department. Conferences and/or written reports are required. Prerequisites: BIMD 500 or consent of instructor.

BMB 996. Continuing Enrollment. 1-12 Credits.

BMB 998. Thesis. 1-9 Credits.

BMB 999. Dissertation. 1-15 Credits.

Office of the Registrar

Tel: 701.777.2711
1.800.CALL.UND
Fax: 701.777.2696

Twamley Hall Room 201
264 Centennial Drive Stop 8382
Grand Forks, ND 58202-8382